[2] After university Luo Huining started working for the provincial government of Anhui, rising to the position of Propaganda Chief of the province in 1999.

In March 2013 he was again promoted to Communist Party Secretary of Qinghai, replacing Qiang Wei who had been transferred to Jiangxi province.

[1][3] In January 2020 Luo succeeded Wang Zhimin as the Director of the Liaison Office of the Central People's Government in Hong Kong by a decision of the State Council.

[6][7][8] His appointment was widely viewed as fall-out from the rout of pro-Beijing candidates in the November 2019 District Council elections.

[10] In August 2020, Luo and ten other officials were sanctioned by the United States Department of the Treasury under Executive Order 13936 by President Trump for undermining Hong Kong's autonomy.