The Lurgan Branch is a railroad line owned and operated by the Norfolk Southern Railway (reporting mark NS) in the U.S. states of Pennsylvania and Maryland.

The line is part of the NS Harrisburg Division and runs from Harrisburg, Pennsylvania southwest to Hagerstown, Maryland along former Reading Company (reporting mark RDG) and Pennsylvania Railroad (reporting mark PRR) lines.

In 1837, the Cumberland Valley Railroad (reporting mark CVRR) opened the line from Lemoyne to Chambersburg, including the Lurgan Branch southwest of Shippensburg.

The PRR line was abandoned from Shippensburg to Carlisle, a portion that saw much street-running and -crossing, as this was the segment that was never significantly improved by the Cumberland Valley Railroad.

NS is preparing for expanded traffic on the Lurgan Branch as part of its Crescent Corridor project.