Lusignan (French pronunciation: [lyziɲɑ̃]) is a commune in the Vienne department in the Nouvelle-Aquitaine region in western France.

Right north of the town flows the river Vonne, a tributary of the Clain.

Between the 10th and 14th centuries, the history of the town fully overlaps with that of the House of Lusignan.

During the 16th century Lusignan is repeatedly involved in the French Wars of Religion between Huguenots and Catholics.

The city walls were dismantled by royal orders in the 17th century.