[2] This atypical form of T-lymphocytes contains T-cell receptors on the surface and is found in both the dermis and epidermis layers of the skin.

Since Lutzner cells are a mutated form of T-lymphocytes, they develop in bone marrow and are transported to the thymus is order to mature.

[3] Lutzner cells develop because of clonal gene rearrangements in the T-cell receptor or antibody.

This rearrangement occurs early in the differentiation process and creates novel T-cell receptors that mimic the structure of normal antibodies but are not able to function properly.

Lutzner cells begin developing in bone marrow then travel to the thymus via the secretion of the hormone thymosin.

These cells have antibodies present on the surface of the extracellular membrane, which contribute to the destruction of the invader or antigen.

[2] Since these mutated antibodies are created early on, they are able to undergo mitosis and produce new T-cell lymphocytes that also contain the novel antigens.

Lutzner cells are more predominant in Mycosis Fungoides, but are also found in Sézary Syndrome.

The only way to tell these two forms of lymphoma apart is to perform a biopsy in order to get a microscopic view of the cancer cells.

[10] Lutzner cells are found in skin tissue, more specifically, the epidermis and dermis layers.

An accumulation of Lutzner cells in the layers of the skin can cause cutaneous T-cell lymphoma.

[11] Two forms of cutaneous T-cell lymphoma associated with abnormal T-lymphocytes or Lutzner cells are Mycosis Fungoides and Sézary Syndrome.