Lux-Pain is set in the historical Kisaragi City, a town plagued by mysteries from small mishaps to murders - with no logical explanation as to why these events occur.

To avenge his parents, Atsuki goes through a dangerous operation to acquire Lux-Pain in his left arm, a power so strong that it turns his right eye golden when using it to seek and destroy Silent for good.

[2] Higashino described the plot as being "dark," and stated that social problems such as truancy, group suicide, mental abuse on the internet, and cruelty to animals inspired him to create the game.

[9] Its localization was almost universally mentioned as being poor, with Austin Shau's GameSpot review noting that it "makes the story harder to follow than it should be," and "results in too much unintentional humor to take any of Lux-Pain's commentary seriously."

The review expressed disappointment over the notion that what could have been a "poignant experience" is ruined by its failure "to deliver on the most basic element of a novel-style adventure," referring to its apparent poor writing.

[11] Daemon Hatfield of IGN remarked, "This graphic adventure doesn't make any sense, and all players are allowed to do is clumsily poke at static scenes and wade through endless pages of poorly-translated dialogue.

"[20] The Daily Telegraph gave a more favorable review, though writer Chris Schilling also mentioned the game's "wonky localisation, with grammatical oddities ranging from female characters being referred to as 'he' to confusion over whether the setting is Japan or America."