[8] At the 70th International Astronautical Congress on October 22, 2019, LSA and NASA signed a memorandum of understanding to work together to further cooperation in lunar exploration, with a particular emphasis on advancing commercial opportunities.

[13] Specifically, the memorandum focused on the LSA acting as a regulatory agency for the numerous private firms based in Luxembourg, to make sure that they were still following NASA guidelines for future Artemis missions.

[14] In 2019 LSA signed a partnership with the European Space Agency (ESA) to promote and develop the research, economic and legal aspects of In-Situ Resource Utilization (ISRU) as a way to reduce costs for future space missions, by having spacecraft produce resources such as fuel in the field.

At the third meeting in 2023 LSA announced the "Lunar Space Resources Accelerator", a fund for private start-up companies to begin developing ISRU programs in Luxembourg.

The project, which is under the oversight of the ESA, will use OffWorld's technical expertise in robotics with a technology demonstration mission slated for launch to the moon in 2027 on SpaceX's Starship HLS.