She is remembered for her innovative designs and for her collaboration with the Italian-born Dutch architect Enrico Hartsuyker.

Considerable attention was paid to their Biopolis project, a satellite city planned for The Hague but never realized.

[4] Their social housing designs included alternative layouts with new spatial options, often with a central patio and slight differences in room levels.

[2] Their urban planning models, Biopolis and Hydropolis, draw considerable attention as they were aimed at integrating various functions in a building development.

[2] In the 1980s, Luzia Hartsuyker became known for her "women-friendly" homes, overcoming the traditionally hierarchical designs with rooms of more equal sizes.