Lyme Brook is a tributary stream of the River Trent, which flows through Newcastle-under-Lyme, and the outlying areas of Stoke-on-Trent in Staffordshire, England.

[3][4] Prior to the 20th century the upper course of the brook could be traced through the area to the north of Newcastle, but subsequent development and culverting means that only parts are now visible.

[5] From Pool Dam, the brook has been designated as main river, which flows south-east in a narrow valley, between Clayton and Trent Vale, where it forms the boundary between Newcastle and Stoke.

The brook then passes next to the Clayton Wood Training Ground and under the A500 dual carriage-way, joining the Trent near Hanford.

The 1995 carved stone sculpture by local artist Ian Randall, shows a cascade of fish returning to the brook.