The lymphatic endothelium refers to a specialized subset of endothelial cells located in the sinus systems of draining lymph nodes.
These lymphatic endothelial cells contribute directly to immune function and response modulation, provide transport selectivity, and demonstrate orchestration of bidirectional signaling cascades.
(Jalkanen, S., Salmi, M. 2020)[1] Until recently, lymphatic endothelial cells have not been characterized to their optimal potential.
This leads to further research that is being developed on the relationship between lymphatic endothelium and metastasis of tumor cells (Pepper, M. S., & Skobe, M. 27 October 2003).
Their origin has been speculated to vary based on them being dependent on specific tissue environments, and powered by organ-specific signals.(L.