[1] Lymphomatoid means lymphoma-like and granulomatosis denotes the microscopic characteristic of the presence of granulomas with polymorphic lymphoid infiltrates and focal necrosis within it.
The disease typically always relapse after successful treatment due to inability of the immune system and current viral drugs to eliminate an EBV-infection.
[4][19] Treatment depends on the grade (I-III) but typically consist of cortisone, rituximab and chemotherapy (etoposide, vincristine, cyclophosphamide, doxorubicin).
However, due to hematopoietic stem cell transplantation being performed only in recent years, this number could potentially be lowered in the future.
In people with CNS involvement, treatment with Interferon alpha at the US National Cancer Institute resulted in complete remission in 90% of patients.