[6] She moved to New York City in the mid to late 1950s to further her study art under Robert Motherwell at Hunter College and Hans Hofmann, under their tutelage she developed an interest in Abstract Expressionism.

[7] Motherwell taught her composition and draftsmanship techniques and the philosophy "that to be an artist meant first and foremost that one had to create work worthy of attention".

[6][7] Drexler's Pattern and Decoration embroidery and patchwork influenced some of her later works, similar designs often appeared in her painting's backgrounds.

[6][9] In an exhibition of seven married couples, Mr. and Mrs. at Alonzo, Drexler's painting "is concerned with juxtaposing diversely patterned areas of vivid colors" while her husband's work was said to reflect "an outer-space, figurative orientation".

[11] The first comprehensive exhibit of her work – showcasing over fifty paintings, photographic images and textiles – ran at the Monhegan Museum in August and September 2008.

[13] In May of 2024, Farnsworth Art Museum launched an exhibition entitled Lynne Drexler: Color Notes that featured a collection of her works along with an accompanied playlist that ran from May 4, 2024 through January 12, 2025.