She is best known for co-creating DreamWorks' The Mighty Ones, co-founding the animation studio Spümcø with John Kricfalusi, Bob Camp, and Jim Smith, and co-developing The Ren & Stimpy Show for Nickelodeon.
[8] In 1986, Ralph Bakshi was hired to direct a music video for the Rolling Stones song "Harlem Shuffle".
[9] In 1987, Bakshi won the contract to draw Mighty Mouse: The New Adventures for the CBS network, and made Kricfalusi one of his directors.
"[17] In 1989, the Spümcø studio was commissioned by the producer Vanessa Coffey to do a pilot episode for what was then known Ren Höek & Stimpy.
[19] Ren & Stimpy was criticized for violence with adult,[24] bathroom,[24] dark and sexual humor that TV scarcely uses; it received critical acclaim[14] and inspired more innovative satirical cartoons such as Beavis and Butt-Head,[25][26] Rocko's Modern Life, South Park, Family Guy, and SpongeBob SquarePants.
[27] During the production of the episode Stimpy's Big Day, Naylor's relationship with Kricfalusi experienced serious strains as she accused him of not doing enough to meet the deadline for the premiere set for 11 August 1991.
[28] David Koenigsberg of the Spümcø studio recalled: "She was building up with all this tension because she felt the deadlines much more oppressively than John did.
[28] Kricfalusi spread rumors that Naylor "was just the girlfriend" who had done nothing for The Ren & Stimpy Show in an attempt to deprive her of employment in the animation industry.
[28] On 18 May 1993, Kricfaulsi's lawyer sent a letter to the Nickelodeon network threatening to sue if Chris Reccardi was credited as the co-director for The Royal Canadian Kilted Yaksmen.