He said that both Liquor and his father are similar in that "George and my Dad believe strongly in discipline and order and rules.

[15][16] George Liquor's first official appearances were in episodes of The Ren & Stimpy Show, a cartoon series that Kricfalusi created, sold to the television channel Nickelodeon, and directed at his studio Spümcø.

[18] Liquor's other major appearance, the episode "Man's Best Friend", was banned from Nickelodeon and was not shown on television for years because of its content.

[15][17]: 7  The arrangement with the network also granted Kricfalusi the rights to Jimmy the Hapless Idiot Boy, used on the company's vanity card.

[20] One story in the first issue of the Dark Horse's Comic Book, George Liquor's Fishing Show, was later made into a webcomic with sound that was featured on the Spümcø website.

Premiering on October 15, 1997,[23][24] The Goddamn George Liquor Program was the first cartoon series to be produced exclusively for the Internet.

[26] In 1999, The Goddamn George Liquor Program won an Annie Award for "Outstanding Achievement in an Animated Interactive Production".

[27] The series spawned an online short called A George Liquor Christmas, also starring him, Jimmy and Pop.

After being fired from The Ren & Stimpy Show, John Kricfalusi used George Liquor in Macromedia Flash advertisements in hopes of creating a series with direct sponsorship without a network.

[24][28] George Liquor has been used in Kricfalusi's advertisements for Barq's Root Beer,[29] the Ultimate Fighting Championship, and the internet communication service Raketu.

[31] George Liquor has consistently appeared in promos for Adult Swim during the final years of John Kricfalusi's career, as he had managed to secure a stable relationship with Williams Street, having worked for Hanna-Barbera in his early years and contributed specials to Cartoon Network.

[32] In 2016, George Liquor has appeared in promos airing on Adult Swim advertising upcoming UFC fights along with other characters such as Slab N' Ernie and Hank Hill.

Originally intended for release in February 2013, production of the short was delayed up until its completion on August 6, 2017[33] despite technical difficulties of the DVD mastering.

[36] Based on Kricfalusi's childhood experience, the short details George purchasing unlabeled silver cans for a cheap price, and his attempts to feed them to his younger nephews, Slab and Ernie (voiced by Eric Bauza and Gabe Swarr).