The club spent most of its history in the Lancashire Combination, before entering the North West Counties Football League in the 1980s and folding after three seasons.
The club entered the Lancashire Combination Division Two in 1904 but only played in the league for one season after finishing bottom.
Lytham entered the FA Cup for the first time in 1925–26 and reached the first round.
After the Second World War, Lytham rejoined the Lancashire Combination Division Two, finishing in the top half of the league in every season through to 1959, gaining promotion to Division One.
In the late 1970s Lytham reached the third round of the FA Vase twice.