Lytleville is an unincorporated community in McLean County, Illinois, United States, located south of Bloomington-Normal, and is approximately 3½ miles northeast of Heyworth in Randolph Township.

Possibly the first water-powered sawmill and grist mill in McLean County were located here, having been built by James Hedrick in 1833.

His brother James Baldwin was the earliest doctor in the community and lived on a farm east of the mill property.

A bustling trading center for dry goods, groceries and whiskey, it contested strongly with Waynesville and Bloomington for the chief place in the future greatness of this part of the county.

A Methodist church, at the south end of State Street, was built in 1874 and sold to the school district in 1886.

Though the attendance dwindled as compared to the large enrollments of former years, it remained a place for public meetings.

This placed the rail line about three miles west of Lytleville, which declined rapidly in the following years as people moved to the new town of Heyworth.