[5] She later scaled this project and founded "Esperanza: The Immigrant Women's Legal Initiative" within the Southern Poverty Law Center in 2006, which she directed for nearly seven years.

[12] While there, she developed a campaign aimed at assisting and empowering Latina workers in the U.S. Ramírez also co-founded Alianza Nacional de Campesinas (the National Farmworker Women's Alliance) with Mily Treviño-Sauceda.

[16] The letter, written on behalf of Alianza members and lending the support and solidarity of Latina farmworkers, went viral and helped spark the TIME’S UP movement.

[18] In August 2019, Ramírez organized the Querida Familia letter, a letter to the Latino community and allies, with America Ferrera, Diane Guerrero, Eva Longoria, Alex Martinez Kondracke, and Olga Segura, after 22 people were murdered in a mass shooting in El Paso by a white nationalist and following immigration raids in Mississippi.

The Latinx House, which is a project within Ramírez's organization Justice for Migrant Women, aims to create gathering spaces to celebrate the best in Latino culture and bring important societal issues to the forefront.