The M-153 designation continues along Wyoming Avenue where it terminates at a junction with Interstate 94 (I-94) and US Highway 12 (US 12) on the city line.

[3][4] In Canton, M-153 initially runs through a residential area, widening to five lanes west of Beck Road.

Numerous strip malls and retail stores line the corridor, and it widens to seven lanes near Haggerty Road.

M-153 meets I-275 at the east end of Canton, at a partial cloverleaf interchange built over the western crossing of Willow Creek, a tributary of the River Rouge.

[3][4] Just after entering Westland, an overpass carries M-153 over a railroad track, flanked on either side by an at-grade frontage road.

The highway crosses the River Rouge north of the Dearborn Country Club west of Evergreen Road.

MDOT's surveys in 2010 showed that the highest traffic levels along M-153 were the 64,956 vehicles daily between the River Rouge and the Southfield Freeway in Dearborn, on average; the lowest counts were the 10,380 vehicles per day between Plymouth Road and the end of the expressway in Superior Township.

[2] Ford Road remained in township jurisdiction until August 29, 1924, when it was transferred to Wayne County control.

[10] The road was widened into a major thoroughfare between Detroit and Ann Arbor in 1934, to relieve congestion on Michigan Avenue.

[2] The highway bypass of Ann Arbor was cancelled by 1935, leaving the western terminus at US 12 (Plymouth Road).