Madathilparambil Seshan Venkitaraman (26 May 1943 – 8 March 2006), known by his stage name M. S. Thripunithura, was an Indian actor who worked in Malayalam film Industry.

Thripunithura acted in over 300 Malayalam films including hit films Oru Minnaminunginte Nurunguvettam (1987), Perumthachan (1990), His Highness Abdullah (1990), Santhwanam (1991), Bharatham and Yoddha (1992).

As a stage artist, he has won the Kerala State Award for Best Actor for his role in the play, Mochanam.

M. S. Thripunithura was married to Bhagyalakshmi and has three daughters Poornima, Pushpa, Pooja.

He died in the early hours of 8 March 2006 after suffering from a cardiac arrest while on a train journey.