The M10 (sometimes referred to as the R368) is a metropolitan route in the Nelson Mandela Bay Municipality in South Africa that connects Gqeberha and Uitenhage.

The M10 begins at a junction with the R102 (Govan Mbeki Avenue) and the M5 (Mount Road) in North End (just north of the Gqeberha City Centre), heading north-west.

At the Booysens Park suburb, the M10 turns northwards onto Nooitgedacht Road and reaches a t-junction with Old Uitenhage Road, where it meets the western terminus of the M14.

The M10 becomes the Old Uitenhage Road north-westwards and meets the western terminus of the M19 west of Despatch, adjacent to the Nelson Mandela Bay Logistics Park.

Here, it becomes Algoa Road and enters Uitenhage Industries, crossing the Swartkops River.