The R75 is a provincial route in Eastern Cape, South Africa that connects Graaff-Reinet with Gqeberha via Despatch, Kariega and Jansenville.

[1] It passes through the large township of Ibhayi before leaving the built up area of Gqeberha (previously known as Port Elizabeth) and intersecting with the M19 metropolitan route at an interchange south-east of Despatch, adjacent to the Azalea Park suburb.

It crosses the Swartkops River and bypasses Kariega Central (previously known as Uitenhage) to the east (where it meets the M6 metropolitan route at an interchange) before meeting the R334 and ending as a dual-carriageway freeway north of Kariega and becoming a single-carriageway.

22 km after its ending as a dual-carriageway, it leaves the Nelson Mandela Bay Metropolitan Municipality.

It then intersects with the R400 (to Riebeek East and Grahamstown) and heads north-west again passing through Jansenville.