The M41 begins at the M4 (Leo Boyd Highway) interchange in uMhlanga Rocks and runs as a double-carriageway freeway for its entire length.

At this interchange, drivers on the M41 are restricted to exiting southbound onto the M4 towards Durban, while only those traveling northbound on the M4 can enter the M41.

As it proceeds further, it connects with the Millennium Way off-ramp before reaching the N2 highway at the Mount Edgecombe Interchange.

After crossing the N2, the M41 continues northwest, with Mount Edgecombe on its southern side and Cornubia to the north, eventually reaching the Flanders Drive off-ramp.

Shortly after this, it ends at an interchange with the R102, positioned between Mount Edgecombe and Phoenix.