The M4 Motorway is a highway in north-west Syria, which runs parallel with its northern border with Turkey.

The M4 runs from Latakia to Saraqib, where it intersects with the "International Road" M5.

Assuming that it shares 60 km with the M5, it arrives until Aleppo, and from there, it has been expanded as a two-lane expressway that continues further east into the Iraqi border, ultimately reaching its destination at Mosul.

In October 2019, the highway became a warzone, as Turkish-backed Syrian rebel forces advanced into the Kurdish-controlled region of Rojava.

[5] On 25 May 2020, the highway was reopened for the first time in seven months since October 2019 in northeastern Syria, after Russian mediation to reopen parts of the road captured last year by Turkish-backed opposition fighters.