The M5 road is a metropolitan route in the City of Tshwane in Gauteng, South Africa.

At the next junction, the M5 meets the R104 route (Stanza Bopape Street).

[5] Leaving Arcadia, the M5 continues northwards and reaches a junction with the M22 route (Soutpansberg Road) in Prinshof (adjacent to the University of Pretoria Basic Medical Sciences Building).

Just after, it becomes one street northwards (Steve Biko Road) for 500 metres before becoming two one-way streets again (Steve Biko Road northwards & Johan Heyns Drive, formerly Hendrik Verwoerd Drive,[6] southwards) at the Steve Biko Academic Hospital and entering the suburb of Gezina (just east of Capital Park).

The M5 continues north from Gezina, passing through Wonderboom South, to reach its northern terminus at a junction with Lavender Road (R101; R513) in Annlin.