The R104 is a regional route in South Africa that is the designation for some of the old sections of roads that were previously the N4, prior to upgrading.

It heads west for about 11 km to reach the outskirts of Mbombela at the intersection with Dr. Enos Mabuza Drive near the Nelsville suburb.

The R104 designation is used again just west of Wonderfontein in Mpumalanga (east of Middelburg), at an intersection with the N4 national route (Maputo Corridor).

It heads west for about 50 km to reach Middelburg, where it ends at a junction with the N11 national route coming from the south just before the Eastdene suburb (east of the town centre).

It then enters the Schoongezicht suburb, where it crosses to the south of the N4 highway as Kaldine Drive, turns west and bypasses Witbank Primary School as Collins Avenue.

At Flora Park, the R104/R511 co-signage leaves the City of Tshwane Metropolitan Municipality and crosses into Hartbeespoort in the North-West Province as Beethoven Street.