[1][2] It connects the south-western part of Soweto (Protea South) with Mulbarton via Diepkloof, Southgate and Glenvista.

Immediately after the Southgate Shopping Centre, the M68 crosses the R82/M1 highway (De Villiers Graaff Motorway) as Columbine Avenue and continues eastwards to pass through the suburbs of Mondeor, Winchester Hills and Suideroord.

[3] 5 kilometres east of the M1/R82 interchange, the M68 meets the M7 road (Kliprivier Drive) and leaves Suideroord to enter the Glenada suburb.

Soon after, the M68 turns southwards and enters the Glenvista suburb, where it meets the M95 road (Bellairs Drive).

It continues southwards to enter the suburb of Mulbarton, where it ends at another junction with the M7 road (Kliprivier Drive).