The R553 is a Regional Route in Gauteng, South Africa that connects Johannesburg with Vanderbijlpark via Eldorado Park, Ennerdale, Evaton and Sebokeng.

[1] Its northern terminus is an interchange with the M1 highway (De Villiers Graaff Motorway) in Johannesburg South (southbound only).

It heads south-west as the Golden Highway and forms an intersection with the M68 road (Columbine Avenue) in Southgate, west of Southgate Shopping Centre and east of Soweto, before meeting the western terminus of the M38 road.

From there, it passes through Eldorado Park (the south-eastern corner of Soweto) in a south-westerly direction before it forms another interchange with the N12 national route (which is now its own highway).

[1] Next, it meets the western terminus of the R557 just after the N1 overbridge and passes in-between Drieziek and Orange Farm (where it meets the western terminus of the R551) before exiting the City of Johannesburg Metropolitan Municipality and entering Evaton and Sebokeng.