The members of this family encode proteins with 50 to 80% sequence identity to each other.

The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

In one study, high levels of MAGE-A3 in lung adenocarcinoma were associated with shorter survival.

[7] MAGE-A3 is a tumor-specific protein, and has been identified on many tumors including melanoma, non-small cell lung cancer, hematologic malignancies, among others.

This article on a gene on the human X chromosome and/or its associated protein is a stub.