The members of this family encode proteins with 50 to 80% sequence identity to each other.

The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

[4] In salivary gland carcinomas, MAGE4 expression correlates to lower-grade histology, lower likelihood of metastases and more favourable survival.

[7] A targeted treatment to use genetically modified autologous T cells is (as of June 2021[update]) undergoing clinical trials.

[8] This article on a gene on the human X chromosome and/or its associated protein is a stub.