[5][6][7] The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family.

The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells.

This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.

[7] MAPRE2 has been shown to interact with APC.

This article on a gene on human chromosome 18 is a stub.