2GT9, 2GTW, 2GTZ, 2GUO, 3HG1, 3L6F, 3MRO, 3MRP, 3MRQ, 3QDM, 3QEQ, 3QFD, 4EUP, 4JFF, 4L3E, 4QOK, 4WJ5, 5E9D231577836ENSG00000120215ENSMUSG00000024806Q16655Q2TA50NM_005511NM_029993NP_005502NP_084269Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA or "MALENA" gene.

[5] A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system.

Kawakami et al. at the National Cancer Institute coined the term MART-1, which stands for "melanoma antigen recognized by T-cells".

Antibodies against the antigen are used in the medical specialty of anatomic pathology in order to recognize cells of melanocytic differentiation, useful for the diagnosis of a melanoma.

This is due to the fact that its high precursor frequency of about 1/1000 among cytotoxic T-cells makes it easy for antigen presenting cells to evoke peptide-specific responses.