The addition of vinca alkaloids (vincristine or vinblastine) to the "7+3" regimen, which was quite popular in AML(ALL?)
This is because vinca alkaloids are rapidly deactivated in myeloid cells by their enzyme myeloperoxidase.
Addition of glucocorticoids (like prednisolone) or methotrexate or alkylating drugs (like cyclophosphamide or melphalan) to the "7+3" regimen is also of no benefit in AML.
It gave rise to the so-called ADE (or DAE = DA + etoposide) induction regimen in AML.
The ADE induction (unlike, say, combinations of 7+3 with vinca alkaloids or prednisolone) is still sometimes used, especially in poor-risk AML patients.