[5][6] Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, multiple sclerosis, and phimosis.

Common side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue.

[9] Common side effects with long-term use include bone loss, weakness, yeast infections, and easy bruising.

[14] Corticosteroids inhibit the inflammatory response to a variety of inciting agents and, it is presumed, delay or slow healing.

[16] Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and autoimmune conditions[17] such as asthma,[18] uveitis, pyoderma gangrenosum, rheumatoid arthritis, urticaria,[19] angioedema,[19] ulcerative colitis, pericarditis, temporal arteritis, Crohn's disease, Bell's palsy, multiple sclerosis,[20] cluster headaches, vasculitis, acute lymphoblastic leukemia, autoimmune hepatitis,[21] lupus, Kawasaki disease,[22] dermatomyositis,[7] post-myocardial infarction syndrome,[23] and sarcoidosis.

[7][26] Prednisolone in lower doses can be used in cases of adrenal insufficiency due to Addison's disease.

[30][31] Some side effects include glaucoma, blurred vision, eye discomfort, impaired recovery of injured site, scarring of the optic nerve, cataracts, and urticaria.

[37] Topical prednisolone can also be used after procedures such as Laser Peripheral Iridotomy for patients with primary angle-closure suspects (PACS) to control inflammations.

[47][14] All of them will collectively cause a sequence of events, including the inhibition of prostaglandin synthesis and additional inflammatory mediators.

[47] Prednisolone predominantly undergoes kidney elimination and is excreted in the urine as sulphate and metabolites of glucuronide conjugate.

[49] Prednisolone is a synthetic pregnane corticosteroid closely related to its cognate prednisone, having identical structure save for two fewer hydrogens near C11.

[53] Prolonged use of prednisolone eye drops in children may lead to raised intraocular pressure.

[56] Prednisolone is used in the treatment of inflammatory and allergic conditions in cats, dogs, horses, small mammals such as ferrets, birds, and reptiles.

[60] It is used in a broad spectrum of diseases, for example, inflammation of scleral tissues, cornea, and conjunctiva in dogs.

[57] Cats with conjunctivitis usually are required to avoid using ophthalmic preparations of corticosteroids and its derivatives.