2C2N27349223722ENSG00000100294ENSMUSG00000048755Q8IVS2Q8R3F5NM_014507NM_173467NM_001030014NP_055322NP_775738NP_001025185Malonyl CoA-acyl carrier protein transacylase, mitochondrial is an enzyme that in humans is encoded by the MCAT gene.

[6] The enzyme encoded by the MCAT gene, along with other enzymes that regulate Malonyl-CoA concentration, have been shown to regulate levels such that malonyl-CoA concentration decreases in human muscle tissue when under exercise training.

This enzyme specifically has increased activity under these conditions, as it is known to catabolize malonyl-CoA.

[7] The human Malonyl CoA-acel carrier protein transacylase in human mitochondria associates with respiratory complex one, such that it interacts functionally with a mitochondrial malonyltransferase.

Both species are encoded by nuclear genes, and their translocation into mitochondria is dependent on the presence of an N-terminal targeting sequence.