The game presents a number of new features, including catcher mode, and Home Run Derby.

[1] Catcher for the Minnesota Twins and 2009 American League MVP Joe Mauer is the cover athlete.

[2] The PlayStation 3 version received "universal acclaim", while the PSP version received "generally favorable reviews", according to the review aggregation website Metacritic.

[17][18] The PlayStation 2 version of the game sold almost 200,000 copies.

[19] During the 14th Annual Interactive Achievement Awards, the Academy of Interactive Arts & Sciences nominated MLB 10: The Show for "Sports Game of the Year".