[1] Under the Champions Cup's updated format starting in 2008–09, the first MLS team to finish first in its group was Real Salt Lake in 2010.
[2] The first Champions League title won by an MLS side occurred in 2022, when Seattle Sounders FC defeated Mexico's UNAM 5–2 on aggregate in the final.
Beginning in 2018, the Champions League format was changed to eliminate group play and the knockout round started with sixteen teams rather than eight.
[6] Notes: The following table shows the performance of MLS teams in the knockout rounds for each home-and-away series for opponents from various leagues.
[12] In 2023, CONCACAF released a new club ranking system ahead of the revamped Champions Cup and regional competitions.
Seattle Sounders FC became champions in 2022, ending Liga MX's winning streak in the competition since 2006.