MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA.
It is believed to be involved in skeletal muscle and glucose metabolism.
[1][2] MOTS-c binds to casein kinase 2.
[3] Researchers discovered MOTS-c in 2015.
[4] MOTS-c is not approved to treat any medical condition and is banned by the World Anti-Doping Agency, explicitly beginning in 2024.