[2] Today, the protein is of further interest because of its role in innate immunity, epidermal cell maturation and epithelial tumorigenesis.
[3] mS100a7a15 overexpression in mammary epithelial cells enhances proliferation, angiogenesis and metastasis through induction of prometastatic and angiogenic factors like CCL2, Cox-2, MMP2, MMP9 and VEGF.
[2] Similar to psoriasin, mS100a7a15 recruits leukocytes and induces proinflammatory chemokines as well as cytokines in keratinocytes through RAGE activation as an alarmin.
[5][7] Similar to its human counterparts, mS100a7a15 mediates inflammation through RAGE (like psoriasin) and through an unknown receptor (like koebnerisin).
The translated mS100a7a15 protein features 109 amino acids, with a calculated molecular weight of 12.87 kDa and a predicted pI of 6.18.