[5] MSC Divina was largely based on the two previous ships in the class, however she was increased in size from 137,936 to 139,400 gross tonnage with 100 additional cabins and facilities and more efficient and energy saving mechanical and electrical systems.

Loren had mentioned to MSC Cruises president, Gianluigi Aponte, that she had wished to have a ship named after her.

[2] Divina has electric propulsion motors and Rolls-Royce folding fin stabilizers to reduce the ship's roll.

[6] From 27 May to 2 June 2012, the MSC Divina cruised in the Mediterranean calling at Civitavecchia in Rome; Messina in Sicily; and Valletta in Malta.

In November, she cruised in the eastern part of the Mediterranean, calling at Kotor, Montenegro; Marmaris, Turkey; and Valletta, Malta.

In late 2013, she repositioned to Miami, Florida, becoming the first MSC vessel in the fleet to serve the North American market, and provided cruises to the Caribbean year round.

On the afternoon of 18 June 2014, a Mexican passenger jumped into the sea, after drinking alcohol for two consecutive days.

Moments after the "man overboard", the MSC Divina stopped, with the captain instructing a search for Amores.

[15] The passenger was aboard MSC Divina after he won a contest organized on the occasion of the 2014 FIFA World Cup by a beer company.

Throughout the passenger's journey aboard the MSC Divina and even shortly before he jumped, he had published his account on the social network Twitter, images and videos which stated the festive atmosphere that existed on board the vessel.

Other passengers reported that the jump was to impress a young host and interviewer of Mexican television, who allegedly he had met on board MSC Divina and who also traveled to Brazil.

[16] In late 2017, MSC Divina was featured in a photo exhibition by Gianni Berengo Gardin underlying the effects of cruise ships on the historical city of Venice.