1ZN41079717768ENSG00000065911ENSMUSG00000005667P13995P18155NM_001040409NM_006636NM_008638NP_006627NP_032664Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is an enzyme that in humans is encoded by the MTHFD2 gene.

[5][6][7] This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.

The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate.

Alternative splicing results in multiple transcripts encoding different isoforms.

This article on a gene on human chromosome 2 is a stub.