A number of personalities from other MTV channels around the world taped short messages which aired on the program.

MTV Live's first guest was Kevin Zegers, a Canadian actor that starred in the movie Transamerica.

The show shared its official on-air launch party with MTV Canada as a channel on April 18, 2006, with live performances by Kanye West and Sam Roberts.

Starting in mid-May 2006, the show started using two hosts for each MTV Live episode, with Daryn Jones acting as the primary host with alternating co-hosts Jessi Cruickshank, Nicole Holness, Dan Levy, and Aliya-Jasmine Sovani.

Once again, the band (and their fans) caused a large amount of damage, destroying the ceiling, spray painting walls and knocking over amps and a motorcycle which was brought into the washroom as a prop.

Since 2010, the show now only has 4 hosts - Daryn Jones, Nicole Holness, Paul "The Intern" Leumieux, and Sheena Snively.

Sheena can usually be seen behind Daryn and Nicole interacting with viewers on a computer, while she also hosts a segment of the show called Sheena on the Street, where she goes out onto the Toronto streets surrounding the studio and asks citizens questions, gives them challenges, and dresses up in costumes.

The following day, he was announced as the host of Over the Rainbow, a reality talent competition scheduled to air on CBC Television in the 2012–13 season.

[7] On November 2, 2012, Bell Media announced the relocation of the MTV Canada studio from the Masonic Temple to 299 Queen Street West,[8] effectively cancelling the program.

[10] The main seating area was made up of rows of circular couches where the hosts and audience sat.

Throughout Hacked, the original MTV Live episode is paused to allow host Johnny Hockin to make comments about the chat, ask questions to viewers and send shout outs to the chatters.