He was the third generation of his family to be chairman of the Muthoot Group,[1] and the former Lay Trustee of the Indian Orthodox Church.

[citation needed] At the time he took over the operations at Muthoot, the Group had 31 branches in four states, namely Kerala, Delhi, Chandigarh, and Haryana.

Muthoot was a member of the executive committee of the Federation of Indian Chambers of Commerce and Industry, and the Chairman of the FICCI Kerala State Council.

[5] M.G George Muthoot was honored with the Distinguished and Outstanding Alumnus of 2015 award instituted by Manipal University.

[9] M. G. George Muthoot died on 5 March 2021 aged 71 at a private hospital in Delhi after falling from 4th floor of his house.