Mabel Catherine Malherbe (9 August 1879 – 1 February 1964) was a South African politician and activist for women's suffrage.

It was whilst working for the Red Cross that she met Kenne Nicholaas De Kock Malherbe, whom she married in 1903.

As a delegate for the South African National Council of women, Mabel Malherbe attended the International Woman's Conference in Geneva.

As a woman that was active in politics before women even had the right to vote, she participated in the creation of the female branch of the National Party in Transvaal in 1915.

During her parliamentary term, she fought to not only advance the rights of women, but also for others marginalised due to difficult economic situations.