[9][10] Oboh started her career in the entertainment industry in the early 80s after her training in cinematograph, stage craft, speech and drama.

She became the second female independent producer and director in Nigeria with her drama series titled Victims that later became a network productions in the '80s and was aired on Nigerian Television Authority (NTA).

[24][25][26] In 2022, she returned back to African Democratic Congress (ADC) and was appointed the Party National Diversity and Inclusion (D&I) Secretary where she would be relating with the electorate.

[27][28] In 2023, she was appointed executive board member, media, and international relations of Conservatives Friends of Africa Scotland, UK (CFoAfricaScotland) and African Democratic Congress (ADC) National Publicity Secretary of the party.

[29][30] She founded the Mabel Oboh Centre for Save our Stars (MOCSOS), with the sole aim of catering to the health needs of Nigerian entertainers.