The series stars Lucas Till, Tristin Mays, Justin Hires, Meredith Eaton, Levy Tran and Henry Ian Cusick.
Monica Macer, who joined the series as an executive producer a month before Lenkov was fired, served as the showrunner for the season.
[20] Series star Lucas Till said that Lenkov's actions, particularly during the first season, caused him to feel suicidal, and drove him to his breaking point.
[21] On August 12, 2020, it was announced that CBS Television Studios had signed a deal with the law enforcement advisory group 21CP Solutions, to consult on its crime and legal dramas, which includes MacGyver.
[24] One of the remaining episodes from the fourth season included a crossover appearance from Jorge Garcia as Jerry Ortega, his character from Hawaii Five-0.
[25][26] On February 18, 2021, it was announced that Alexandra Grey had been cast in a recurring role as Parker, a transgender female Phoenix engineer who assists the team.
[27] The following day, Ernie Hudson and Wendy Raquel Robinson were revealed to have been cast as Milton and Lauretta Bozer, the parents of Hires' character, Wilt.
[32] Kelly Kahl, CBS' Entertainment President, stated about the decision "All of us at CBS are extremely grateful for the incredible work and dedication from Lucas and the rest of the cast, as well as Monica, the writers and the entire crew, the MacGyver team traveled far and wide to repeatedly save the world with little more than bubble gum and a paper clip and made this show distinctly their own.
We're gratified we get to give this dedicated and loyal fan base the opportunity to say goodbye to their favorite characters in the thoughtful manner this series deserves.
[37] 1.35 million paperclips, a signature tool of Angus MacGyver's were sent to CBS Studio Center in Los Angeles, California,[38] with several thousand more sent directly to Kahl's office in New York City.
[34] The planned sixth season would have included a Black Hawk Down-style episode centered around Tran's character, Desi, and her presumed dead ex-fiancé, Evan.
[41] In a rough scriptment for the fifth season finale, titled "Biometric + Compass + Paperclip + Family + Goodbye",[41] the episode would have featured a time jump to the year 2035 that introduced the future son of MacGyver and Riley.