In his first collegiate game against Robert Morris, O'Keefe scored seven goals, earning him Big Ten Offensive Player of the Week honors.

That summer, he played for the Orangeville Northmen of the Ontario Junior Lacrosse League, where he scored 33 points in 15 games.

He would finish his career with 221 goals, including scoring in his final 43 games, and second all time in Penn State history with 269 points.

O'Keefe signed a two-year contract with Archers in the 2023 offseason as a free agent, reuniting with Penn State teammate Grant Ament.

Source:[9] GP–Games played; G–Goals; 2PG–2-point goals; A–Assists; Pts–Points; Sh–Shots; GB–Ground balls; Pen–Penalties; PIM–Penalty minutes; FOW–Faceoffs won; FOA–Faceoffs attempted Mac O'Keefe PLL bio