Maccabi Rehovot was founded in 1950 and played in the Liga Artzit (the third-tier division).

During the nineties, Rehovot was coached by Moti Aroesti, a former Maccabi Tel Aviv player, and played in the Liga Leumit.

In the 2015–16 season, Rehovot was promoted to the Liga Leumit for the first time in 17 years.

[1] In the 2017–18 season, Rehovot reached the Liga Leumit Semifinals as the third seed but eventually lost to Maccabi Kiryat Gat.

[2] In the 2018–19 season, Rehovot have been relegated to the Liga Artzit, the third tier of the Israeli Basketball.