[1] It was founded in Fort Wayne, Indiana, United States, in 1922, by Macedonian Bulgarian immigrants originating mainly from Greek Macedonia.

[3] The first Macedonian Bulgarian emigrant associations in the United States date back to 1899, with the foundation of the "Macedonian-Bulgarian Society Vasil Levski".

In September 1913, delegates from Macedonian organizations in the United States and Canada gathered in Chicago, Illinois to form a Macedonian-Bulgarian National Union.

[5] When World War I was over, a "Bulgarian National Congress" was held in Chicago in December 1918, where the delegates voted for a resolution which was sent to the Paris Peace Conference and to the governments of the Great Powers.

[9] Fort Wayne in Indiana was chosen as the site for the first formative convention, which took place on October 2, 1922, with a handful of delegates, most of whom were Ilinden veterans.

The newspaper was founded under the name Macedonian Tribune, and its publication began under the guidance and leadership of the MPO Central Committee's Secretary Jordan Tchkatroff on February 10, 1927.

[14] Tchkatroff's activities raised the attention of Yugoslav diplomatic and consular services in the US, which already had a watchful eye over the MPO.

[17] This was acknowledged by a CIA analyst report from 1953, which dubbed the MPO as "the US branch of the IMRO", and asserted that through its then secretary Luben Dimitroff, it acted as a money-raising organ to support Mihailov's activities.

[8] In the case of Socialist Yugoslavia, the MPO initially sent a letter to President Josip Broz Tito congratulating him on the establishment of an autonomous Macedonia within the federation,[20][better source needed] however, the organization soon raised its voice against the historiographic revisionism that was taking place in Yugoslavia,[citation needed] which aimed at diminishing the Bulgarian cultural and historic heritage in Macedonia.

[21] His influence in the MPO was eventually diminished, when a younger generation of leaders, led by Ivan Lebamoff and Christo Nizamoff, confronted Mihailov's authoritarianism, and removed his supporters from leadership positions.

The delegates agreed on a common goal – a free and independent Macedonia, and the result of the forum was a resolution in which they demanded the international recognition of the country.

[27] The Greek Orthodox Archdiocese of America also demanded that the Republic of Macedonia's independence not be recognized by the United States.

In reaction to this, Lebamoff sent protest letters against this position to the patriarchs and bishops of Eastern Orthodox Churches worldwide as well as to numerous newspapers.

Lebamoff asked Indiana Senator Lugar to propose that the United States send US troops to the Republic of Macedonia.

[29] In 1994, members of the MPO Central Committee visited Washington, D.C., several times to promote Macedonian American interests.