The Macintyre River, a perennial river that forms part of the Border Rivers group, is part of the Barwon catchment of the Murray-Darling basin, located in the Northern Tablelands and North West Slopes regions of New South Wales, and the Southern Downs region of Queensland, Australia.

[2] Part of the course of the river marks the border between Queensland and New South Wales.

[6] The Macintyre River descends 1,040 metres (3,410 ft) over its 319-kilometre (198 mi) course;[3] passing near the towns of Glen Innes, Inverell, Ashford, Yetman, and Boggabilla.

Peter Macintyre was a pastoralist and land owner of Segenhoe Station in the Hunter River district.

[2] The Macintyre River is often affected by floods and the town of Goondiwindi is protected by levee banks that can cope with a water level rise of nearly 11 metres (36 ft).