The station serves the town of Macksville, and opened on 1 July 1919 when the line was extended from Kempsey.

The property was added to the New South Wales State Heritage Register on 2 April 1999.

[2] Macksville railway station was listed on the New South Wales State Heritage Register on 2 April 1999 having satisfied the following criteria.

[2] The place possesses uncommon, rare or endangered aspects of the cultural or natural history of New South Wales.

[2] This Wikipedia article contains material from Macksville Railway Station group, entry number 01184 in the New South Wales State Heritage Register published by the State of New South Wales (Department of Planning and Environment) 2018 under CC-BY 4.0 licence, accessed on 2 June 2018.