[1] Although not easily visible to the public, the original 1873 Roma Street railway station building still exists within the modern complex and is listed on the Queensland Heritage Register.

[2] The construction of a railway station on Roma Street was part of a plan to extend the Main Line to Brisbane.

An iron station building designed by Sir Charles Fox & Sons was to be imported from the United Kingdom for this purpose, but economic problems in Queensland led to the order being cancelled.

In 1873, the Superintendent of Public Buildings Francis Stanley designed a smaller station for the site, with construction beginning in the same year under John Petrie.

[2][4] Following the opening of the Merivale Bridge on 18 November 1978, Roma Street was also served by Beenleigh line services.

[9] Visitors not travelling on Queensland Rail services can obtain a free pass to transit through the station concourse from Roma Street to the parklands.

Brisbane Metro Line 2 services will continue through Roma Street following the existing Northern Busway route, with the next stations being Normanby (northbound) and King George Square (southbound).

[14] Due to the anticipated demolition of the Brisbane Transit Centre, a temporary long-distance bus terminal was constructed on the opposite side of Roma Street Station (near Platform 10) and opened in September 2019.